Neuroscientist · Neural-Engineering Tool Developer

I build the tools that record the brain.

Postdoctoral researcher at UCLA designing wireless miniature microscopes, open-source neural devices, and scientific software — bridging optics, electronics, and data science to capture neural activity in freely behaving animals.

Dr. Marcel Brosch
PhD
summa cum laude · faculty thesis prize
9
publications & conference papers
150+
citations · h-index 4 (Scholar)
UCLA
current postdoc, Aharoni Lab

About

Neuroscience meets engineering

I'm a neuroscientist and tool developer who turns hard measurement problems into devices and software people can actually use. My work sits at the intersection of optics, electronics, microfabrication, and data science — building instruments that record the brain with higher fidelity, lower cost, and fewer constraints on natural behavior.

During my PhD (summa cum laude) at the Leibniz Institute for Neurobiology in Germany, I developed two open-source neural recording devices: a transparent µECoG array for combined electrophysiology and optical imaging, and TetrODrive, a 3D-printed microdrive that costs under $25. Both were published as first-author papers and are used by other labs.

As a postdoc in the Aharoni Lab at UCLA, I co-lead Miniscope Zero — a fully wireless, single-cell-resolution miniature microscope that frees neural imaging from tethers and large batteries. Alongside the hardware I build the data-acquisition and analysis software that goes with it. I also completed a full-time data analytics bootcamp (Python, ML, SQL), reflecting where I want to take these skills next: solving applied problems where rigor, prototyping, and data fluency matter.

I care about making technology accessible and staying involved in the science community. I co-founded SimpleNeuro, a science-communication blog written by young researchers for the public (archived), served as PhD student representative for 50+ graduate students, and review for Nature Methods.

Selected Research

Tools I designed and built

Each project is an end-to-end device — concept, hardware, firmware/software, and validation in vivo. Findings and figures below are drawn from the original publications and manuscripts.

Current · UCLA · Co-first author (in preparation)

Miniscope Zero — fully wireless brain imaging

Sasatani & Brosch et al. · Aharoni Lab, UCLA

In plain terms: a tiny microscope worn on a mouse's head lets us watch individual brain cells light up while the animal moves freely — and we made it work with no cables or heavy batteries holding it back.

A head-mounted, single-photon miniature microscope that records single-cell neural dynamics in freely behaving mice with no tether and no bulky battery. Power is delivered wirelessly via Quasistatic Cavity Resonance (>500 mW over 2,500 cm²) and data streams over an 8 Mbps optical uplink. Upgraded optics deliver 2.6× the light-collection of the UCLA Miniscope v4, enabling multi-hour CA1 recordings during 3D-maze navigation and multi-animal social interaction.

Co-first-authored with Takuya Sasatani (University of Tokyo). I led the miniature microscope and wireless data link; wireless power was developed in collaboration with Takuya.

Optical designWireless data linkEmbedded firmwareCalcium imagingPlace-cell analysis
Miniscope Zero system architecture and optics
System architecture: wireless power cavity, optical data link, and optics that collect 2.6× more light than Miniscope v4.
Miniscope Zero in action — wireless single-cell imaging during freely behaving navigation (SfN 2025).
First author · J. Neural Eng. 2021

TetrODrive — an open-source microdrive

Brosch, Vlasenko, Ohl & Lippert · J. Neural Eng. 18:046030

In plain terms: a small, 3D-printed gadget that gently lowers hair-thin sensors into the brain to listen to single neurons — built for under $25 instead of the usual several hundred.

A 3D-printable microdrive for combined electrophysiology and optophysiology in mice. It weighs under 1.5 g, assembles in 15 minutes, and costs under $25 — versus hundreds for commercial units. A key innovation mechanically decouples plugging forces from the drive body for stable recordings across sessions, and a movable fiber enables fiber photometry. We validated it with optogenetically identified single units in the ventral tegmental area.

3D printing / CADMechanical designOptogenetics / optotaggingIn vivo electrophysiology
TetrODrive components, assembly, and head-mounted use
Components, assembly steps, and the assembled drive on a mouse — under 1.5 g, built for under $25.
First author · J. Neural Eng. 2020

Transparent µECoG array

Brosch et al. · J. Neural Eng. 17:046014

In plain terms: a see-through electrode film that rests on the brain's surface, so we can record its electrical activity and shine light through it at the same time — thinner than a human hair and stable for months.

An optically transparent multi-electrode array for simultaneous surface electrophysiology and optogenetics/imaging. Built from ultra-thin polyimide with chrome-gold-platinum traces, the array is just 6.5 µm thick and ~83% transparent to blue light, while rejecting opto-electric artifacts. It records stable ECoG over months without measurable degradation and maps the tonotopic organization of the curved rodent auditory cortex — a robust, low-cost alternative to fragile graphene/ITO devices.

MicrofabricationMaterials / opticsECoG & voltage imagingChronic biocompatibility
Transparent micro-ECoG array: layout, transmittance spectrum, and fabrication
The array, its ~83% optical transmittance across optogenetic wavelengths, and the thin-film fabrication process.

Software & Open Source

Code that powers the science

Beyond hardware, I build and contribute to the software stack around neural imaging — from data acquisition to analysis GUIs — much of it open source and used across the Miniscope community.

Capabilities

What I bring to a team

A rare combination of scientific rigor and hands-on building — from data pipelines and software to physical prototypes that ship and get used. Hover any skill to see the projects behind it.

Software & Programming

PythonUsed inMiniscope ZeromioCaTunePandas / NumPyUsed inMiniscope Zeromioscikit-learn (ML)FromData Analytics training (Ironhack)MATLABUsed inCAVEµECoG arrayMSc thesisC / C++ (embedded)Used inMiniscope ZeromioMySQLFromData Analytics training (Ironhack)GUI developmentUsed inCaTuneCAVEmioSignal & image processingUsed inMiniscope ZeroCAVEµECoG arrayGit / GitHubUsed inmioCaTuneTetrODriveOpen-source maintenanceUsed inmioTetrODriveCAVEAPIs & web scrapingFromData Analytics training (Ironhack)Data visualizationUsed inCaTuneCAVEMiniscope Zero

Hardware & Engineering

CAD & 3D printingUsed inTetrODriveMiniscope ZeroMicrofabricationUsed inµECoG arrayPCB / electronicsUsed inMiniscope ZeroTetrODriveOptical designUsed inMiniscope ZeroµECoG arrayEmbedded firmwareUsed inMiniscope ZeroWireless power & dataUsed inMiniscope ZeroRapid prototypingUsed inTetrODriveMiniscope ZeroDevice validationUsed inMiniscope ZeroTetrODriveµECoG array

Neuroscience Methods

1-photon calcium imagingUsed inMiniscope ZeroCaTuneCAVEIn vivo electrophysiologyUsed inTetrODriveµECoG arrayMSc thesisOptogeneticsUsed inTetrODriveµECoG arrayECoG / tetrodesUsed inµECoG arrayTetrODriveMSc thesisFiber photometryUsed inTetrODriveStereotactic surgeryUsed inMiniscope ZeroTetrODriveµECoG arrayHistologyUsed inµECoG arrayTetrODriveBehavioral assaysUsed inMiniscope ZeroMSc & BSc theses

Communication & Leadership

Scientific writingBehind7+ publicationsThree thesesPeer review (Nature Methods)RoleJournal manuscript reviewerInvited talksIncludesGerman Neuroscience MeetingGerman Physiology SocietyScience communicationFoundedSimpleNeuro blogMentoringRolePhD representative (50+ students)Project leadershipUsed inMiniscope ZeroTetrODriveCross-disciplinary collaborationExampleMiniscope Zero

Experience & Education

Career path

2022 — present

Postdoctoral Researcher

Aharoni Lab · UCLA · Los Angeles, USA

Developing tools that address current challenges in neuroscience and medicine, with a focus on one-photon imaging with wireless miniature microscopes (Miniscope Zero) and the open-source software around them.

2022

Data Analytics Graduate

Ironhack · Full-time bootcamp (remote, Amsterdam campus)

Python data analytics, MySQL, building/evaluating/deploying ML models (scikit-learn), inferential statistics, APIs, web scraping, and data visualization.

2016 — 2022

Dr. rer. nat. (Doctorate in Natural Science) summa cum laude 🏆 Faculty Prize — Best PhD Thesis

Developed neuroscience tools combining electrophysiology and optophysiology: a transparent µECoG array and the TetrODrive optrode microdrive. Awarded the Faculty of Biology’s Promotionspreis for the best doctoral dissertation of the year. Advisors: Prof. F. Ohl, Dr. M. Lippert.

2013 — 2016

M.Sc. Integrative Neuroscience

Leibniz Institute for Neurobiology · Magdeburg, Germany

Thesis on functional auditory cortico-striatal coupling during two-way active avoidance learning, combining ECoG, local field potentials, and behavioral analysis.

2010 — 2013

B.Sc. Biology

University Hospital Jena, Germany

Thesis optimizing the Barnes maze protocol to reliably detect differences in spatial learning between cyclin D2 knockout and wild-type mice — quantifying how protocol parameters (e.g., inter-trial intervals) affect measurable memory performance.

Publications

Peer-reviewed work

Selected journal articles and conference papers. First-author work in bold.

2026
Wireless power transfer for neural recording devices in freely behaving animals: current solutions and future directions
Aharoni D, Brosch M, Sasatani T
Proc. SPIE 13889 · Optical Power Delivery II
2025
Projection-specific optogenetic stimulation of visual cortex for neuroprosthesis
Vlasenko A, Altun E, de Schultz T, Brosch M, Ohl FW, Lippert MT
Brain Stimulation 18 · conference abstract (P3.006)
2021
TetrODrive: an open-source microdrive for combined electrophysiology and optophysiology
Brosch M, Vlasenko A, Ohl FW, Lippert MT
Journal of Neural Engineering 18:046030
2020
An optically transparent multi-electrode array for combined electrophysiology and optophysiology at the mesoscopic scale
Brosch M, Deckert M, Rathi S, Takagaki K, Weidner T, Ohl FW, Schmidt B, Lippert MT
Journal of Neural Engineering 17(4):046014
2019
Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating
Coors A, Brosch M, Kahl E, Khalil R, Michels B, Laub A, Franke K, Gerber B, Fendt M
Journal of Ethnopharmacology 235:320–328
2019
Electrochemical roughening and carbon nanotube coating of tetrodes for chronic single-unit recording
Xia Z, Arias-Gil G, Deckert M, Vollmer M, Curran A, Herrera-Molina R, Brosch M, Krug K, Schmidt B, Ohl FW, Lippert MT, Takagaki K
bioRxiv 738245
2018
Predator odour but not TMT induces 22-kHz ultrasonic vocalizations in rats that lead to defensive behaviours in conspecifics upon replay
Fendt M, Brosch M, Wernecke KEA, Willadsen M, Wöhr M
Scientific Reports 8(1):10041
2018
CAVE: an open-source tool for combined analysis of head-mounted calcium imaging and behavior in MATLAB
Tegtmeier J, Brosch M, Janitzky K, Heinze H-J, Ohl FW, Lippert MT
Frontiers in Neuroscience 12:958
2017
Neurobiological fundamentals of strategy change — a core competence of a companion system
Schulz AL, Woldeit ML, Brosch M, Ohl FW
International Conference on Companion Technology (IEEE 8287074)

Plus the Miniscope Zero wireless-imaging manuscript in preparation (co-first author, UCLA). Invited talks include the German Neuroscience Meeting (2019) and the German Physiology Society (2016); Best Talk Award, Young Physiologists Symposium (2015).

Contact

Let's talk

Open to roles in neurotech and biotech — spanning R&D, instrumentation and hardware, and data science. I'm always glad to talk and happy to share my code or device designs.